Experimental Investigation into the Duration of Tolerance to Re-Infection in Monkey Malaria
نویسنده
چکیده
Resume of previous work Knowles (1934) made the following observations in regard to the development of tolerance in monkey malaria. Between November' 1932 and August 1933, a Silenus rhesus monkey was given four injections with monkey plasmodium, treated each time with small doses of quinine, and developed a chronic infection, which apparently cleared up. On 7th August, 1933, it was given a 5th injection of infected blood, with no response. On 30th August, 1933, it was given a 6th injection (one-sixth of this amount is usually needed to produce a severe infection in a normal animal). There was no response. On 14th October, 1933, a still larger dose was given. After an incubation period of 11 days, the parasites appeared in the peripheral blood, but the rate of multiplication was much slower than in
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